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Pharmacology Midterm Exam Study Guide: NKU MSN 611, Exams of Health sciences

This study guide provides a comprehensive overview of key concepts in pharmacology, covering topics such as antihistamines, antimicrobials, tuberculosis treatment, chemotherapy, autonomic agents, and more. It includes questions and answers, making it a valuable resource for students preparing for a midterm exam in pharmacology.

Typology: Exams

2023/2024

Available from 12/09/2024

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NKU Pharmacology Midterm Exam MSN 611 New study set 2024 | Actual
Questions and Answers Latest Updated 2024/2025 (Graded A+)
As a neurotransmitter in the brain Answer✔✔Histamine that is not found within mast cells functions
Convulsions, postural hypotension, cardiac arrhythmias Answer✔✔Toxic effect of first-generation
antihistamines
Epinephrine is mainstay medication. Antihistamines will not be able to treat it alone
Life-threatening reaction that requires medical intervention. Causes significant physical distress, impairs
ability to swallow and breath.
Itchy rash, swelling of tongue, bronchoconstriction, hypotension, facial edema
Presents suddenly Answer✔✔Know anaphylaxis
Sedative properties, CNS depression - beers list for elderly Answer✔✔Central nervous system side effect
of antihistamines in the elderly
inhibit the secretion of gastric acid in patients with GI disorders. Answer✔✔Indication H2 antihistamines
Typically empiric - before causative pathogen has been identified.
Started on broad-spectrum antibiotics before pathogen is confirmed.
Consider: pt hx, age, pregnancy, renal fx, liver fx, type of infection, infection site, cost of medication
Cultures obtained for infections such as pneumonia Answer✔✔Know initial selection of antimicrobial
therapy
Food-drug or drug-drug may decrease the absorption of the antibacterial medication
Decreased by separating administration times or avoiding the combination Answer✔✔Mechanism of
food-drug or drug-drug interactions with antibacterial medications
drug regimen typically 3.6 months.
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NKU Pharmacology Midterm Exam MSN 611 New study set 2024 | Actual

Questions and Answers Latest Updated 2024/2025 (Graded A+)

As a neurotransmitter in the brain Answer✔✔Histamine that is not found within mast cells functions Convulsions, postural hypotension, cardiac arrhythmias Answer✔✔Toxic effect of first-generation antihistamines Epinephrine is mainstay medication. Antihistamines will not be able to treat it alone Life-threatening reaction that requires medical intervention. Causes significant physical distress, impairs ability to swallow and breath. Itchy rash, swelling of tongue, bronchoconstriction, hypotension, facial edema Presents suddenly Answer✔✔Know anaphylaxis Sedative properties, CNS depression - beers list for elderly Answer✔✔Central nervous system side effect of antihistamines in the elderly inhibit the secretion of gastric acid in patients with GI disorders. Answer✔✔Indication H2 antihistamines Typically empiric - before causative pathogen has been identified. Started on broad-spectrum antibiotics before pathogen is confirmed. Consider: pt hx, age, pregnancy, renal fx, liver fx, type of infection, infection site, cost of medication Cultures obtained for infections such as pneumonia Answer✔✔Know initial selection of antimicrobial therapy Food-drug or drug-drug may decrease the absorption of the antibacterial medication Decreased by separating administration times or avoiding the combination Answer✔✔Mechanism of food-drug or drug-drug interactions with antibacterial medications drug regimen typically 3.6 months.

Active TB Initial treatment phase: 2 months daily - isonizid, rifampin, pyrazinaminde, ethambutol. Continuation phase: 4 or 7 months Isonizid with rifampin. Total of 6 or 9 months Latent TB infection (LTBI) Isoniazid: daily or twice weekly for 6-9 months. Rifampin: daily for 4 months Isonizid + rifampentine: weekly for 3 months Multidrug-resistant TB (MDR-TB) Susceptible fluoroquinolone and injectable second-line agent (capreomycin or amikacin) Regimens of at least five drugs recommended Extensively drug-resistant TB (XDR-TB) MDR-TB + additional resistance to fluoroquinolone and at least one of the second-line agents. Treatment individualized Answer✔✔Know multiple drug combination treatment for tuberculosis Fibroblast interferon: released by human cells infected with certain viruses. IFN-B products have antiviral properties but are used for MS, not infections Answer✔✔Know about description of IFN-β Protozoal pathogen. Transmission of tissue parasites (sporozoites) into bloodstream by infected mosquitos Answer✔✔Type of pathogen causes malaria Neoadjuvant therapy - reduce tumor burden, ⇧ effectiveness of local treatment Answer✔✔Why systemic chemotherapy that is given prior to surgery or radiation is given Adequate IV hydration, allopurinol if hyperuricemia is anticipated. Answer✔✔Tumor lysis syndrome management in leukemia patients Hemorrhagic cystitis Answer✔✔Acrolein is a toxic metabolite of cyclophosphamide and ifosfamide that can cause what Immunosuppressant antineoplastic agents Answer✔✔Category of antineoplastic drugs offers an alternative when traditional treatments fail Topoisomerase enzymes Answer✔✔Topoisomerase inhibitors target enzymes that control changes in DNA

Esmolol & Labetolol Answer✔✔Beta-blocker indicated for hypertensive emergencies Ace inhibitors ARBs Potassium sparing diuretics Renin inhibitors Answer✔✔Know renin-angiotensin-aldosterone inhibitors Phenylephrine (ICU therapy) Flecainide (Preventative) Adenosine Answer✔✔Therapeutic management of paroxysmal supraventricular tachycardia Parkinson's disease Answer✔✔D2 receptors are a drug development target for which disease? Behavioral changes, GI symptoms, gingival hyperplasia, osteomalacia, megaloblastic anemia, hirsutism Steven-Johnson syndrome, toxic epidermal necrolysis, systemic lupus erythematosus, neutropenia, leukopenia, hepatic necrosis Answer✔✔Adverse effects of chronic phenytoin Ramelteon Tasimelteon Answer✔✔Which drug in the anxiolytic, sedative, and hypnotic category is a melatonin agonist Brain stem Answer✔✔The "triptans" exert their serotonin 1B and serotonin 1D agonist effects in the: Motion sickness Answer✔✔Indication of some first-generation antihistamines with antinausea and antiemetic Nicotine - mainstay for smoking cessation Nicotine agonists - alternative aid Answer✔✔Success in smoking cessation

Nausea, abd pain, diarrhea, CNS advers effect - cinchonism (tinnitus, delirium, hearing/visual impairment) Answer✔✔Know adverse effects of quinidine include a set of central nervous system symptoms Endothelium - promote vasodilation Answer✔✔Nitrates cause nitric oxide to be released from where Reye's syndrome Answer✔✔Acetaminophen is the drug of choice to treat fevers in children and young adults to prevent what condition Geriatric, children Answer✔✔Types of patients are second-generation antihistamines the preferred form of treatment Ascariasis: Round worm; Albendazole or pyrantel pamoate Symptoms: abd pain, abd obstruction, vomiting, appendicitis if in lungs: PNE, fever, cough, eosinophilia, pulm infiltrates Trichuriasis: Whipworm; Albendaxol or Ivermectin Symptoms: GI symptoms, malnourishment, rectal prolapse Answer✔✔Differentiate symptoms of ascariasis and trichuriasis. Treatment failure, disease - changes in fungal species Answer✔✔Significant clinical consequences of antifungal resistance. Myelosuppressive QT prolongation: baseline and periodic ECG, electrolyte levels monitored and corrected Answer✔✔Potential toxic effects of vorinostat and romidepsin and procedures used to monitor for them. Form covalent bonds with kinase domains of the epidermal growth factor receptors > downregulation of signaling and inhibition of cell proliferation Associated with skin toxicities Answer✔✔Mechanism of action of second-generation tyrosine kinase inhibitors