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·etrovmicoscopy^ those^ cases^
due to^ innue^ Complex^ deposition
e *uptures^ in GBM - regardless of type . ↓ A severe (^) injury that allows^ leukocytes^ ,Plasma^ proteins
such as
Coagulation factors^ & complement^ &^ inflammatory medictory to^ reach^ the^ urinary^ space .
↓ · (^) trigger E cents formation.
inical (^) feature!
· henature with^
blood casts^ in^
unive · moderate^ proteinuria
· (^) hypertension &^ edema - ·d posture^ syndrome^
recurrent henopsis r e rhage · ephrotic (^) Syndrome's
- caused by derangement^ in (^) glomerular capillary^
wall
resulting inted (^) permeability to plasma proteins^
I racterised (^) by r · Massive (^) proteinuria
- loss (^) of 3. 5g (2) more^ protein · Hypoalbuminemia-plasma albumin levels^ <Sgld · generalized adema : · Hyperlipidemic & Lipiduria
- (^) depletes serve albumin beyond Capacity
↓ Ccolloidosmotic^ Pressure)
leads - to goerdised
edema
- O ↓ & (^) Thrombotic (^) Ethromboembolic &^ leakage of lipoproteins^ across complications are^ also^ common the glomerularCapillary^
wall -
in nephrotic Syndrome^
-^ *Lipids (^) appear in^ urine^ either a (^) free fat (or) asfat bodies-
Ripoto
kidney en (^) often
associatedita
mk- abetes , Anyloidosis &
SLE-
Autoantibody binding to PLA2 R · Complement Activation & shedding of immune aggregates from the^ cell surface to · forms characteristic (^) deposits of immune^ complexes^ along the subepithelial aspect^ .
of
Bm
genecular capillary wall is^ leaky ? -- --
IgG4-main immunoglobulin
d y
ExogenousAg (^) EndogenousAg · derived^ from Hep 5
· renal cors non rena
Treponema pallidum & M^.^ GN^ in^ SLE^ is associated^ with (^) deposition of complexes (^) ofnuclear proteins^ & (^) And antibodies . ↑ most (^) notable associations :
Morphology lightmicroscopyh e glomeruli appear
numl C)^
exhibit (^) uniform , diffuse thickening (^) of the glomerular capillary^ wall. = By
electron
microscopy !- & (^) thickening is^ seen^
to be^
caused (^) by irregular^ electron- dense (^) deposits containing immune complexes blos ·laying epithelia^ cells , with (^) effacement of podocyte foot processes.
