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These notes provide an overview of gregor mendel's groundbreaking work in genetics, focusing on his discoveries regarding inheritance using the common garden pea as his experimental organism. Mendel identified the existence of genes, dominant and recessive traits, and the concept of alleles. He also established mendel's laws of segregation and independent assortment, which laid the foundation for the field of genetics. This document also covers the concept of polygenic inheritance and the determination of human blood types.
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CHAPTER 11 NOTES – Mendel and His Discoveries Inheritance is viewed as a “black box” Genetics – the study of inheritance Study began with Gregor Mendel (Austrian Monk and naturalist) Had no knowledge of chromosomes, meiosis or DNA Used scientific method Experimental Organism – Pisum sativum (common garden pea) Performed in present-day Czech Republic Genes – elements of NA located on chromosomes Make up 2% of DNA BASES A – Adenine T – Thymine C – Cytosine G – Guanine Cycle of a Pea Plane
Recessive represented by (^) lower case letters Genotype – genetic makeup of an individual Phenotype – features and characteristics of an individual Determined by its genotype under some conditions and its environment under others Yellow seeds were dominant (Y) Green seeds were recessive (y) Parental generation “P generation” Offspring of P “F 1 generation” (first filial generation) Offspring of F 1 “F 2 generation” (second filial generation) What did Mendel learn? No “blending” of characteristics Heredity is due to the transmission of discrete elements Green seeds were absent from F 1 Green seeds reappeared in F 2 F 1 individuals retained a green-seed element Traits are caused by PAIRS of elements F 1 individuals must possess a yellow-seed element F 1 individuals also possess a green-seed element Pairs of elements represent genes
Paired genes exist on pair of homologous chromosomes Alternative forms of genes are called “alleles” Homozygous – having two identical alleles of a gene for a given character Genotype YY Homozygous Dominant Genotype yy Homozygous recessive Chapter 11 Part II Heterozygous – possessing two different alleles of a gene for a given character Genotype Yy Heterozygous F 2 generation has 3 different genotypes YY, Yy, yy F 2 generation also has 2 different phenotypes Yellow and green F 2 generation displays 2 different ratios Genotypic ratio 1:2:1 YY:Yy:yy Phenotypic ratio 3:1 Yellow:Green YY and Yy have same phenotype Mendel’s Law of Segregation Individuals possess two alleles for each gene These alleles separate during gamete production Dominant allele an allele that is phenotypically expressed in a heterozygote Recessive allele an allele that is NOT phenotypically expressed in a heterozygote Yy genotype is yellow phenotype Mendel’s Law of Independent Assortment During gamete formation, gene pairs assort independent of one another The transmission of one character does NOT influence the transmission of another The field of genetics is founded upon Mendel’s work Polygenic Inheritance many other traits, governed by multiple genes, more than 2 alleles for many genes Blood types are determined by types of glycoprotein on the surface of the red blood cells Type of glycoprotein is genetically determined by single gene on chromosome 9 Human blood types A, B, AB, O Type A has most glycoprotein Type O has no glycoprotein “A” allele “A” molecule “B” allele “B” molecule “O” allele inactive (no molecule encoded) Six combinations of alleles for four blood types