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Immunology and Serology exam 1
Typology: Exams
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Immunology & Serology exam 1 The main process by which cells of the Innate Immune system defend against foreign material is: ✔✔phagocytosis Which of the following cells involved in innate immunity is NOT part of the myeloid blood cell line? ✔✔Natural Killer Cells The first line of defense in protecting the body from infection includes all of teh following components EXCEPT ✔✔lymphocytes Which of the following cells involved in innate immunity does not originate in the blood? ✔✔dendritic cells The most effective phagocytic blood cell is the ✔✔The most effective phagocytic blood cell is the If I have a bruise on my arm, which acute phase reactant will bind the hemoglobin and bring it to the liver to be cleared? ✔✔haptoglobin What is the name of the process by which phagocytic cells are attracted toward a substance such as a bacterial peptide? ✔✔chemotaxis The principal type of leukocyte in the process of phagocytosis is the ✔✔monocyte Cells that can act as antigen processing cells (APCs) for exogenous antigens include ✔✔macrophages/monocytes and dendritic cells The type of immunity that follows the injection of antibodies synthesized by another individual or animal is termed ✔✔passive A major advantage of passive immunization as opposed to active immunization is that ✔✔antibody is available more quickly When a phagocytic cell engulfs a bacteria, the bacteria in in the cellular compartment known as ✔✔phagosome Mast cells are the tissue form of which blood cell? ✔✔basophils The type of immunity that follows the injection of an antigen is termed ✔✔active This complex system of proteins plays a number of different roles in the innate immune system ✔✔Complement
Which complement components result in the osmotic lysis of cells? ✔✔membrane attack complex Which complement pathway requires Immunoglobulin to become activated? ✔✔Classical Which components do all three complement pathways have in common? ✔✔C3, C5, C6, C7, C8, C Which complement component is most commonly measured because it has the highest blood concentration? ✔✔C Which of the following is NOT one of the complement activation pathways? ✔✔coagulation pathway The insertion of the membrane attack complex on the bacterial surface causes one of the following ✔✔osmotic cytolysis What is the purpose of C3a, C4a, and C5a, the split products of the complement cascade? ✔✔to cause increased vascular permeability, contraction of smooth muscle, and release of histamine from basophils Which of the following complement components is found in both the classic and alternative pathways? ✔✔C After activation of the complement system, leukocytes and macrophages are attracted to the site of complement activation by ✔✔C5a Which complement component is present in the greatest concentration in human serum? ✔✔C All of the following are immunologic functions of complement EXCEPT ✔✔production of antibodies The alternate pathway for complement activation: ✔✔A) bypasses steps C1-C B) can be activated by bacterial capsule polysaccharides C) can be activated by properdin D) all of the above <---- Which of the following is an opsonin? ✔✔C3b Which of the following complement proteins is NOT part of the membrane attack complex? ✔✔C Which of the following is the worst clinical deficiency to have? ✔✔C To be immunogenic, which of the following is NOT important? ✔✔charge For a substance to be immunogenic, it must be ✔✔recognized as non-self Antigenic determinants and epitopes are the same thing. ✔✔True
T cells recognize fragments of antigen complexed with MHC protein displayed on the surface of cells ✔✔True CD4 on T cells binds to ✔✔MHC Class II Molecules Certain T cells play a role in the process of humoral (antibody-mediated) immunity. ✔✔True Plasma cells secrete _________________ rather than expressing them on their cell surface. ✔✔immunoglobulins T cells mature in the: ✔✔thymus The major class of immunoglobulin found in adult human serum is: ✔✔IgG Which class of immunoglobulin possesses 10 potential antigenic binding sites? ✔✔IgM Which immunoglobulin class most often exists as a dimer? ✔✔IgA Which immunoglobulin class(es) has/have a J chain in their structure? ✔✔IgM and IgA Which immunoglobulin class is the predominant class found in secretions? ✔✔IgA Which of the following statements applies to the Fc fragment of an immunoglobulin molecule? ✔✔it is produced by the action of papain on a complete immunoglobulin molecule Which class of immunoglobulin possesses delta heavy chains? ✔✔IgD Which region of the immunoglobulin molecule can bind antigen? ✔✔Fab What is the predominant type of antibody found in the serum of neonates born after full-term gestation? ✔✔material IgG Which type of antibody is capable of placental transfer? ✔✔IgG Which class of immunoglobulin binds to basophils and mast cells to mediate immediate allergic reactions? ✔✔IgE Which of the following statements about immunoglobulin light chains is true? ✔✔there are two types, kappa and lambda The structure that holds two basic units together in a dimeric IgA molecule is a: ✔✔j chain
After initial exposure to antigen, the first antibodies that can be detected belong to the class: ✔✔IgM Which immunoglobulin class primarily serves as a cell membrane receptor on B cells? ✔✔IgD Which immunoglobulin class cross-links with mast cells to release histamine? ✔✔IgE What region determines immunoglobulin class? ✔✔heavy chain constant region How does the secondary immune response differ from the primary immune response? ✔✔A) all are true <---- B) the antibody levels produced are higher in the secondary response C) the lag phase (the time between exposure to antigen and production of antibody) is shorter in the secondary immune response D) IgG is the predominant antibody class produced in the secondary immune response Which immunoglobulin appears first in the primary immune response? ✔✔IgM __________________ immune responses are those in which memory cells are activated following encounter with antigen. ✔✔secondary Which of the following characteristics is NOT TRUE of an anamnestic response compared to a primary response? ✔✔IgM antibodies predominate Which immunoglobulin appears in the highest titer in the secondary response? ✔✔IgG