Determination of Water Vapor Transmission Capacity of
Pharmaceutical Packaging Materials
Water vapor transmission capacity refers to the amount of water vapor through the
specimen in a certain period of time under the specified temperature, relative
humidity, and certain water vapor pressure. The main role of the drug bottle is to
protect the safety of drugs in the process of storage and transportation, to ensure the
stability of the validity period. Water vapor transmission amount can reflect the
barrier performance of the bottle, if this indicator exceeds the standard, it is easy to
cause moisture in the long storage of drugs, affecting the safety of medication.
Whether the water vapor transmission capacity of the bottle meets the standard is
related to the purity of the raw materials used, the control of the production process,
the quality of the mold and other factors, high-quality packaging is the key to protect
the safety of drugs, but also an effective way to improve the added value of the
product.
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Pharmaceutical solid bottles in the water vapor transmission amount of the test, is
generally to be specified in the temperature and humidity, and water vapor pressure to
be able to test, or there is a high risk of other accidents. If the test is done under the
specified environment, then the permeability can be obtained within a certain period
of time.
Mainly choose the cup method to determine, the operation steps are roughly as
follow:
Weigh a certain amount of dried absorbent in the permeable cup, and fix the measured
material on the permeable cup. Subsequently, molten sealing wax is poured into the
groove of the permeable cup, and after the sealing wax has solidified, the permeable
cup is put into the constant temperature and humidity box, and after a certain period
of time, it is taken out from the box and put into the desiccator at a constant
