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Cell Cycle: Phases, Proteins, and Regulation, Study notes of History of Education

Southern Illinois University (SIU) - Carbondale History of Education

An overview of the cell cycle, including the different phases (g1, s, g2, and m), the proteins involved (cyclins and cyclin-dependent kinases), and the mechanisms of regulation (cdk phosphorylation, c degradation, c & cdk synthesis, and cdk inhibition). Notable proteins include p53, p21, and prb.

Typology: Study notes

Pre 2010

Uploaded on 07/30/2009

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12/3/08

Cell Cycle

Eric Niederhoffer

SIU-SOM

6-8 h

DNA, RNA,

Protein

3-4 h

RNA, Protein

1 h

Mitosis, Cytokinesis

G2 Cyc D’s

CDK4,6

Cyc B/A

CDK1

Cyc A

CDK2

Cyc E

CDK2

6-12 h RNA, Protein

p53

pRb

Lamin

Abl

Cyc: cyclin CDK: cyclin dependent kinase RNA: ribonucleic acid

p53: cell cycle control protein, MW 53kDa, also involved in other phases of cell cycle

pRb: retinoblastoma protein DNA: deoxyribonucleic acid

H1: histone H1 Abl: Abelson interacting protein

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G

Cell Cycle Eric Niederhoffer SIU-SOM

G

6-8 h

DNA, RNA,

Protein

3-4 h

RNA, Protein

1 h

Mitosis, Cytokinesis

S

G2 Cyc^ D ’ s

CDK4,

Cyc B/A

CDK

Cyc A

CDK

M

Cyc E

CDK

6-12 h RNA, Protein

p pRb Lamin H Abl Cyc: cyclin CDK: cyclin dependent kinase RNA: ribonucleic acid p53: cell cycle control protein, MW 53kDa, also involved in other phases of cell cycle pRb: retinoblastoma protein DNA: deoxyribonucleic acid H1: histone H1 Abl: Abelson interacting protein

Variation in Cell Cycle Cyclins

M G 1 S G 2 M G 1

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